This text aims to provide simplified practical guidelines to start a hematopoietic stem cell transplantation unit which could be implemented in most centers and countries worldwide. The book also provides guidelines for existing transplantation units to upgrade their practice and implement new policies and procedures, in addition to developing therapies according to latest international standards and regulations. The book covers a wide range of practical implementation tools including HSCT program team structure, building inpatient and outpatient HSCT units, requisite laboratory support for transplantation program, practical aspects of stem cell collection and processing, HSCT program quality management, education and training, and data management. The book also addresses cost effectiveness and recommendations for establishing transplantation program in countries with limited resources. Written by group of internationally established experts in their corresponding hematopoietic stem cell transplantation fields, with contributions from many leaders of hematopoietic stem cell transplantation organizations, Establishing a Hematopoietic Stem Cell Transplantation Unit: A Practical Guide is an essential, practical resource for all members of the multidisciplinary hematopoietic stem cell transplantation team.
Practical Hematopoietic Stem Cell Transplantation is the only comprehensive yet practical guide to the total care of the transplant patient. It provides a ready source of reference to help health care professionals involved in the management of patients requiring bone marrow and stem cell transplantations – covering many of the infections and complications that may arise. An essential, practical manual for all those working in the field of bone marrow and stem cell transplantation A balanced practical text aimed at the whole multi-disciplinary team Easy to use - practically organized - covering all aspects of pre and post transplant care – including social and psychological aspects Experienced and well respected editorial team Whether you are an established specialist in hematology/oncology, nursing specialist, trainee, or any other member of the hematopoietic stem cell transplant team, this book will answer all your questions about the medical, social and psychological pre and post transplant, patient care.
A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.
A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.
Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship
Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.
This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program.
The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).
This unique book is the first on pediatric hematopoietic stem cell transplantation that is especially intended for pharmacists – in recognition of the fact that Pediatric Oncology Pharmacy is an area where more and more specific knowledge is required in daily practice, yet pharmacists who work in pediatric stem cell transplantation do not have a book addressing their specific needs. This pioneering book will likely become the new gold standard for practice, addressing subjects such as stem cells and their differentiation mechanisms; aspects of embryonic and non-embryonic stem cells; stem cell transplantation in pediatrics; stem cell sources and related technical choices; stem cell donors; scheduling transplantations; diseases and chemotherapy protocols that require stem cell transplantation; stem cell homing; engraftment and repopulation of stem cells in bone marrow; autologous stem cell transplantation in pediatrics; allogeneic stem cell transplantation in pediatrics; and indications for autologous and allogeneic pediatric stem cell transplantation. Further, it discusses pediatric graft-versus-host disease and the pharmacist; antibacterial and antifungal prophylaxis; detailed chemotherapy, conditioning and trials for pediatric stem cell transplantation; conditioning granulocyte colony-stimulating factor (G-CSF) in pediatric stem cell transplantation; analyzing prescriptions and programming a pediatric stem cell transplantation; handling chemotherapy and adjuvant drugs for pediatric stem cell transplantation; stem cell transplantation in children up to 1 year old; and clinical pharmacy in pediatric stem cell transplantation. An easy-to-read yet comprehensive guide covering a wide range of topics essential to daily practice, the book offers an invaluable asset for pediatric hemato/ oncology pharmacists, hematologist pharmacists, clinical pharmacists, pediatric pharmacists, pharmaceutical residents and researchers alike.
Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
Since the publication of the first edition of this book in 2004, the specialty of hematopoietic stem cell transplantation (HSCT) has continued to progress as a treatment option for many diseases. Indications for the use of autologous, syngeneic, and allogeneic transplantation continue to expand. The second edition of Hematopoietic Stem Cell Transplantation: A Manual for Nursing Practice presents the most up-to-date information regarding the use of HSCT. Chapter topics include an overview of hematopoiesis and immunology, basic concepts of transplantation, stem cell collection, course of transplant treatment and acute complications, acute and chronic graft-versus-host disease, various complications from gastrointestinal to neurologic, relapse, long-term care and survivorship, ethics, and much more.
Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource. Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research Combines the knowledge and expertise of over 170 international specialists across 106 chapters Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at www.wiley.com/go/forman/hematopoietic.
