Natural Products in the Treatment and Management of Diabetes

Natural Products in the Treatment and Management of Diabetes

Author: Mamdouh Moawad Ali

Publisher: LAP Lambert Academic Publishing

ISBN: 3659498432

Category:

Page: 60

View: 510

Diabetes mellitus is the most common metabolic disorder characterized by the presence of hyperglycemia due to defective insulin secretion, defective insulin action or both. Traditional Medicines derived from medicinal plants are used by about 60% of the world's population. We focus on herbal drugs and plants used in the treatment of diabetes. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In Egypt it is proving to be a major health problem, especially in the urban areas. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications, herbal formulations are preferred due to lesser side effects and low cost. A list of medicinal plants with proven antidiabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. One of the etiologic factors implicated in the development of diabetes and its complications is the damage induced by free radicals and hence an antidiabetic compound with antioxidant properties would be more beneficial. Therefore information on antioxidant effects of these medicinal plants is also included.

Antioxidant-Antidiabetic Agents and Human Health

Antioxidant-Antidiabetic Agents and Human Health

Author: Oluwafemi Oguntibeju

Publisher: BoD – Books on Demand

ISBN: 9789535112150

Category: Medical

Page: 384

View: 755

The human system employs the use of endogenous enzymatic as well as non-enzymatic antioxidant defence systems against the onslaught of free radicals and oxidative stress. Enzymatic antioxidants and non-enzymatic antioxidants work synergistically with each other, using different mechanisms against different free radicals and stages of oxidative stress. Dietary and lifestyle modifications are seen as the mainstay of treatment and management of chronic diseases such as diabetes mellitus. The major aims of dietary and lifestyle changes are to reduce weight, improve glycaemic control and reduce the risk of coronary heart disease, which accounts for 70- 80% of deaths among those with diabetes. It is also important to note that medicinal plants have been used as medicines since ancient time, and continue to play significant role even in modern medicine in management and treatment of chronic diseases. Impressive numbers of modern therapeutic agents have been developed from plants. Phytochemicals have been isolated and characterised from fruits such as grapes and apples, vegetables such as broccoli and onion, spices such as turmeric, beverages such as green tea and red wine, as well as many other sources. The WHO estimates that approximately 80% of the worlds inhabitants rely on traditional medicine for their primary health care and many medicinal plants have ethno-medical claims of usefulness in the treatment of diabetes and other chronic diseases globally, and have been employed empirically in antidiabetic, antihyperlipidemic, antihypertensive, antinflammatory and antiparasitic remedies. This book examines the role of antioxidant-rich natural products in management and treatment of diabetes and other chronic diseases.

Alternative Medicines for Diabetes Management

Alternative Medicines for Diabetes Management

Author: Varma H. Rambaran

Publisher: CRC Press

ISBN: 9781000728637

Category: Science

Page: 235

View: 445

Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies. Alternative Medicines for Diabetes Management: Advances in Pharmacognosy and Medicinal Chemistry provides a holistic view of all oral therapies for diabetes mellitus that are available to the public by removing the silos and stigmas that are associated with both allopathic and ayurvedic medicines. Additional Features Include: Highlights the potential role of dietary and medicinal plant materials in the prevention, treatment, and control of diabetes and its complications. Educates readers on the benefits and shortcomings of the various present and potential oral therapies for diabetes mellitus. Allows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compounds. Presents the history, nomenclature, mechanisms of action and shortcomings for each of the various sub-classes of allopathic therapeutants for diabetes mellitus and then introduces ayurvedic medicines. Section C discusses various metallopharmaceuticals and provides a holistic view of all available and potential therapies for the disease.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

Author: Atta-ur-Rahman

Publisher: Elsevier

ISBN: 9780128179086

Category: Science

Page: 440

View: 566

Studies in Natural Products Chemistry, Volume 66 covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in new drug development for the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Structure and Health Effects of Natural Products on Diabetes Mellitus

Structure and Health Effects of Natural Products on Diabetes Mellitus

Author: Haixia Chen

Publisher: Springer Nature

ISBN: 9789811587917

Category: Medical

Page: 307

View: 931

The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.

Natural Products in Obesity and Diabetes

Natural Products in Obesity and Diabetes

Author: Biswanath Dinda

Publisher: Springer Nature

ISBN: 9783030921965

Category: Biochemistry

Page: 567

View: 329

This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models. In addition, it examines how genomics and multi-omics approaches have revolutionized our understanding of these diseases, and discusses the role of microbiome-host interactions, probiotics, prebiotics and the future of metabolic phenotyping. Focusing on the pharmacokinetics of anti-obesity and anti-diabetic phytochemicals, their bioavailability in the respective target tissues and their elimination times, the book also describes the nanoformulations of phytochemicals and herbal extracts. Lastly, it presents an overview of the advances in clinical studies on the use of herbal and mushroom extracts in obesity and diabetes management. Given its scope, this book is useful not only for researches in the field but also for students studying nutrition, food sciences, plant sciences or pharmacology, as well as for health professionals and practitioners.

Medicinal Natural Products: A Disease-Focused Approach

Medicinal Natural Products: A Disease-Focused Approach

Author:

Publisher: Academic Press

ISBN: 9780128210208

Category: Science

Page: 530

View: 782

Medicinal Natural Products: A Disease-Focused Approach, Volume 55 in the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition, with chapters in this new release covering Medicinal Natural Products – An Introduction, Anticancer Natural Products, Antimicrobial Natural Products, Antimalarial and Antiparasitic Natural Products, Anti-inflammatory Natural Products, Neuroprotective Natural Products, Hepatoprotective Natural Products, Nephroprotective Natural Products, Cancer Chemopreventive Natural Products, Antipsoriatic Natural Products, Medicinal Natural Products in Osteoporosis, Antidiabetic Natural Products, Anti-obesity Natural Products, and much more. Presents a disease-focused perspective Includes the latest on the medicinal chemistry of natural products Covers natural products in drug delivery

Phytotherapy in the Management of Diabetes and Hypertension: Volume 3

Phytotherapy in the Management of Diabetes and Hypertension: Volume 3

Author: Mohamed Eddouks

Publisher: Bentham Science Publishers

ISBN: 9789811459115

Category: Medical

Page: 234

View: 810

Medicinal plants are a source of potential therapeutic compounds. Phytotherapy can give patients long term benefits with less or no side effects. This is the third volume of the series which features monographs on selected natural products used to treat diabetes and hypertension. This volume brings 7 chapters contributed by 22 researchers, that cover updates on the biochemistry of diabetes, information on anti-diabetic and antihypertensive properties of oil bearing plants, herbs, fruits and vegetables, medicinal plants from Asia, as well as the medicinal value of specific plants such as, star apple (Chrysophyllum cainito). In terms of therapeutic agents, two reviews in this volume focus on terpenoids and glucagon-like peptide – 1 are also included. Each review covers different plant species or medicinal agents where applicable, providing readers essential information about their role in the treatment of diabetes and hypertension. Both academic and professional pharmacologists as well as clinicians will find comprehensive information on a variety of therapeutic agents in this volume.

Natural Products in Clinical Trials: Volume 2

Natural Products in Clinical Trials: Volume 2

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

ISBN: 9789811425752

Category: Medical

Page: 280

View: 700

Natural compounds continue to play a key role in drug development. Many clinically approved drugs are either unmodified natural products or their semi-synthetic derivatives. This book series presents reviews of exciting new bioactive natural products that have huge potential as drugs. Each volume presents comprehensive chapters contributed by eminent scientists. The volumes focus on drug candidates which are in the later stages of drug development and are being evaluated in clinical trials. The series, therefore, highlights the importance of natural products in our lives. The second volume covers the following topics: - A review of recent patents and natural products in clinical trials to treat schistosomiasis - Natural products: the new intervention regimen for metabolic disorders - Fluorine-containing drugs and drug candidates derived from natural products - Natural products for the management of cardiovascular diseases - Implication of natural compounds for the prevention of ocular diseases.

Natural Products Pharmacology and Phytochemicals for Health Care

Natural Products Pharmacology and Phytochemicals for Health Care

Author: Debarshi Kar Mahapatra

Publisher: CRC Press

ISBN: 9781000095579

Category: Business & Economics

Page: 258

View: 816

Medicinal chemistry and pharmacology are closely associated fields, and the use of natural products for their medicinal properties is ever-growing. The study of drugs from natural products and their effects on the living body are explored in this volume. The book looks into the research, discovery, and characterization of chemicals that exhibit biological effects. Providing an informative compilation of research, valuable case studies, and reviews of existing literature in the area, the book focuses on the ethnobotanical uses of natural products and phytochemicals for health care, including applications for diabetes, ulcers, wound healing, chronic alcoholism, hemorrhoidal treatment, cancer mitigation, pain management, immunotherapy, and more.

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products

Author: Goutam Brahmachari

Publisher: Elsevier

ISBN: 9780128096925

Category: Science

Page: 332

View: 462

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Bioactive Phytochemicals: Drug Discovery to Product Development

Bioactive Phytochemicals: Drug Discovery to Product Development

Author: Javed Ahmad

Publisher: Bentham Science Publishers

ISBN: 9789811464461

Category: Medical

Page: 238

View: 553

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.